Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults
DOI:
https://doi.org/10.35898/ghmj-71967Keywords:
FTO polymorphism rs9939609, Obesity, AdultAbstract
Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism
Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity.
Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis.
Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710).
Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity.
Downloads
References
Abdelmajed, S. S., Youssef, M., Zaki, M. E., Abu-Mandil Hassan, N., & Ismail, S. (2017). Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents. Genes and Diseases, 4(3), 170–175. https://doi.org/10.1016/j.gendis.2017.06.002
Central Bureau of Statistics, B. I. (2018). Prevalence of Obesity in Population aged > 18 years according to sex. https://www.bps.go.id/indicator/30/1781/1/prevalensi-obesitas-pada-penduduk-umur-18-tahun-menurut-jenis-kelamin.html
Cho, H. W., Jin, H. S., & Eom, Y. Bin. (2021). The interaction between FTO rs9939609 and physical activity is associated with a 2-fold reduction in the risk of obesity in Korean population. American Journal of Human Biology, 33(3), 1–10. https://doi.org/10.1002/ajhb.23489
çöl, N., Demircioglu-Kiliç, B., Nacak, M., & Araz, M. (2017). Adolescent obesity and the role of the fat mass and obesity-associated gene polymorphism. Clinical and Investigative Medicine, 40(6), E235–E242. https://doi.org/10.25011/cim.v40i6.29124
do Nascimento, G. A., Teixeira, M. D., Furtado-Alle, L., Leite, N., de Souza, R. L. R., Saliba, L. F., ... & Tureck, L. V. (2019). FTO rs9939609 A allele influences anthropometric outcome in response to dietary intervention, but not in response to physical exercise program. European journal of nutrition, 58, 325-334. https://doi.org/10.1007/s00394-017-1596-7
Janssen, I., Katzmarzyk, P. T., Boyce, W. F., Vereecken, C., Mulvihill, C., Roberts, C., Currie, C., Pickett, W., Ńemeth, í., Ojala, K., Ravens-Sieberer, U., Todd, J., & Woynarowska, B. (2005). Comparison of overweight and obesity prevalence in school-aged youth from 34 countries and their relationships with physical activity and dietary patterns. Obesity Reviews, 6(2), 123–132. https://doi.org/10.1111/j.1467-789X.2005.00176.x
Larder, R., Cheung, M. K. M., Tung, Y. C. L., Yeo, G. S. H., & Coll, A. P. (2011). Where to go with FTO? Trends in Endocrinology and Metabolism, 22(2), 53–59. https://doi.org/10.1016/j.tem.2010.11.001
Ministry of Health, I. (2018). Basic Health Research 2018. Ministry of Health, Indonesia, 53(9), 1689–1699.
Panuganti, K. K., Nguyen, M., Kshirsagar, R. K., & Doerr, C. (2022). Obesity (Nursing). StatPearls Publishing, Treasure Island (FL). http://europepmc.org/books/NBK568702
Tung, Y. C. L., & Yeo, G. S. H. (2011). From GWAS to biology: Lessons from FTO. Annals of the New York Academy of Sciences, 1220(1), 162–171. https://doi.org/10.1111/j.1749-6632.2010.05903.x
Yang, Y., Gao, X. H., Tao, X. J., Gao, Q. H., Zhang, Y. H., & Yang, J. J. (2019). Combined effect of FTO and MC4R genepolymorphisms on obesity in children and adolescents in Northwest China: a case-control study. Asia Pacific Journal of Clinical Nutrition, 28(1), 177–182. https://doi.org/10.6133/apjcn.201903_28(1).0023
Zhao, N. N., Dong, G. P., Wu, W., Wang, J. L., Ullah, R., & Fu, J. F. (2019). FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis. World Journal of Pediatrics, 15(4), 382–389. https://doi.org/10.1007/s12519-019-00254-2
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Tiar Masykuroh Pratamawati, Angel Angriani Elma Budai Sadji, Gara Samara Brajadenta, Donny Nauphar
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
GHMJ (Global Health Management Journal) conforms fully to The Budapest Open Access Initiative (BOAI) and DOAJ Open Access Definition. Authors, readers, and reviewers are free to Share ” copy and redistribute the material in any medium or format, and Adapt ” remix, transform, and build upon the material. Author(s) retain unrestricted copyrights and publishing rights of their work. The licensor cannot revoke these freedoms as long as you follow the license terms. Learn the details at the License policy.
How to Cite
