Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults

Authors

  • Tiar Masykuroh Pratamawati Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.
  • Angel Angriani Elma Budai Sadji Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.
  • Gara Samara Brajadenta Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.
  • Donny Nauphar Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.

DOI:

https://doi.org/10.35898/ghmj-71967

Keywords:

FTO polymorphism rs9939609, Obesity, Adult

Abstract

Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism

Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity.

Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis.

Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710).

Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity.

References

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Published

2024-03-15

How to Cite

Pratamawati, T. M., Sadji, A. A. E. B. ., Brajadenta, G. S., & Nauphar, D. (2024). Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults. GHMJ (Global Health Management Journal), 7(1), 27–32. https://doi.org/10.35898/ghmj-71967

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Section

Research Articles

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