Correlation between Duration of Antiretroviral Therapy and Glomerular Filtration Rate in People Living with HIV/AIDS: A Cross-sectional Study in Cirebon, West Java, Indonesia
DOI:
https://doi.org/10.35898/ghmj-81s1182Keywords:
Antiretroviral therapy, Glomerular Filtration Rate, People Living with HIV/AIDSAbstract
Background: West Java ranks the highest Province with Human Immunodeficiency Virus (HIV) case in 2023. An estimated 1.648 patients estimated receive antiretroviral therapy (ART). Kidney disease contributes mortality amongst people living with HIV/AIDS (PLWH). Tenofovir disoproxil fumarate (TDF)-based ART was associated as risk factor of kidney disorders, indicate by declining glomerular filtration rate (GFR). However, there is limited study whether kidney disease among PLWH were related to ART use in Indonesia.
Aims: To determine correlation between duration of antiretroviral therapy and glomerular filtration rate (GFR) in people living with HIV/AIDS.
Methods: This is an observational study with cross-sectional design. Eighty-nine HIV patients on antiretroviral therapy for at least three months with normal baseline GFR were studied. Estimated GFR calculated using the Cockcroft-Gault equation. Data obtained were analyzed with spearman correlation test.
Results: Among 89 subjects, as many as 38 patients (42.7%) on therapy less than 12 months, 29 patients (32.6%) were on ART more than 24 months, and 22 patients (24.7%) 12-24 months. ART with normal kidney function were 62 patients (69.7%). Whereas 29.2% were mildly decrease GFR, and only 1.1% were mild to moderate decrease GFR. The analytical statistic showed a no significant between duration of antiretroviral therapy and GFR in PLWH with a p-value of 0.199 and Spearman’s r of 0.137.
Conclusion: There was no significant correlation between duration of antiretroviral therapy and glomerular filtration rate in PLWH.
Downloads
References
Adnani, H., Agrawal, N., Khatri, A., Vialet, J., Zhang, M., & Cervia, J. (2022, April 1). Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review. Journal of the International Association of Providers of AIDS Care. SAGE Publications Inc. https://doi.org/10.1177/23259582221089194
Agbaji, O. O., Abah, I. O., Ebonyi, A. O., Gimba, Z. M., Abene, E. E., Gomerep, S. S., … Kanki, P. J. (2019). Long Term Exposure to Tenofovir Disoproxil Fumarate-Containing Antiretroviral Therapy Is Associated with Renal Impairment in an African Cohort of HIV-Infected Adults. Journal of the International Association of Providers of AIDS Care, 18. https://doi.org/10.1177/2325958218821963
Anastasie, W. M., Yannick, G., Jonathan, K. K., Reine, K., Khatibat, A., Mélanie, T. W., & Ouattara, B. (2023). Prevalence of Chronic Kidney Disease and Associated Factors among HIV Patients in the Era of HAART in Ivory Coast: A Cross Sectional, Analytical Study. Open Journal of Nephrology, 13(01), 20–30. https://doi.org/10.4236/ojneph.2023.131004
Daniel Kaufman, A. P., Basit, H., & Knohl Affiliations, S. J. (n.d.). Physiology, Glomerular Filtration Rate. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK500032/?report=printable
Eggleton, J. S., Shivaraj, ;, & Affiliations, N. (n.d.). Highly Active Antiretroviral Therapy (HAART) Continuing Education Activity. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK554533/?report=printable
Juhaefah, A., Paramita, S., Kosala, K., & Gunawan, C. A. (2020). Gambaran Karakteristik Pasien HIV/AIDS Yang Mendapat Antiretroviral Therapy (Art). Jurnal Medika Karya Ilmiah Kesehatan (Vol. 5). https://doi.org/10.31219/osf.io/hqa2b
KEMENKES. (2023). Laporan Eksekutif Perkembangan HIV/AIDS Dan Penyakit Infeksi Menular Seksual (PIMS) Triwulan I 2023. Retrieved from https://hivaids-pimsindonesia.or.id/download?kategori=Laporan%20Triwulan
Kementrian Kesehatan Republik Indonesia. (2022). BERITA NEGARA REPUBLIK INDONESIA. Retrieved from www.peraturan.go.id
Komisi Penanggulangan AIDS Kota Cirebon. (2022). DATA KASUS HIV DAN AIDS KUMULATIF YANG DITEMUKAN. Retrieved from https://kpacirebonkota.or.id/data-kasus-kumulatif/
Manaye, G. A., Abateneh, D. D., & Niguse, W. (2020). Chronic kidney disease and associated factors among HIV/AIDS patients on HAART in Ethiopia. HIV/AIDS - Research and Palliative Care, 12, 591–599. https://doi.org/10.2147/HIV.S276356
Mwanjala, M. N., Urio, L. J., & Mtebe, M. V. (2022). Prevalence and predictors of renal dysfunction among people living with HIV on antiretroviral therapy in the Southern Highland of Tanzania: a hospital-based cross-sectional study. Pan African Medical Journal, 41. https://doi.org/10.11604/pamj.2022.41.137.27025
Noerliani Upt, D., Kesehatan, P., Murnajati, M., & Timur, J. (2022). Persepsi Masyarakat Terhadap HIV/AIDS Dan ODHA Sebagai Upaya Untuk Menurunkan Stigma Masyarakat Terhadap Penderita HIV/AIDS Di Desa Krebet Kecamatan Pilangkenceng Kabupaten Madiun Tahun 2016, 1(1). Profil Kesehatan Indonesia 2022. https://doi.org/10.51878/healthy.v1i1.853
Thompson, M. A., Horberg, M. A., Agwu, A. L., Colasanti, J. A., Jain, M. K., Short, W. R., … Aberg, J. A. (2021). Primary Care Guidance for Persons with Human Immunodeficiency Virus: 2020 Update by the HIV Medicine Association of the Infectious Diseases Society of America. Clinical Infectious Diseases, 73(11), E3572–E3605. https://doi.org/10.1093/cid/ciaa1391
WHO. (2023). UNAIDS DATA 2023.
World Health organization. (2023). People living with HIV People acquiring HIV People dying from HIV-related causes. Retrieved from https://apps.who.int/iris/handle/10665/360348
Yuriandro, P., Yunihastuti, E., Marbun, M. B. H., & Nugroho, P. (2019). Faktor-Faktor yang Memengaruhi Terjadinya Penurunan Cepat Laju Filtrasi Glomerulus pada Pasien HIV/AIDS dengan Pengobatan Tenofovir Disoproksil Fumarat. Jurnal Penyakit Dalam Indonesia, 6(3), 141. https://doi.org/10.7454/jpdi.v6i3.334
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2025 Tiara Sekar Ayudhipasha, S.Ked., dr. Menik Herdwiyanti, Sp.PD., FINASIM , dr. Sedayu Sp.PD
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
GHMJ (Global Health Management Journal) conforms fully to The Budapest Open Access Initiative (BOAI) and DOAJ Open Access Definition. Authors, readers, and reviewers are free to Share ” copy and redistribute the material in any medium or format, and Adapt ” remix, transform, and build upon the material. Author(s) retain unrestricted copyrights and publishing rights of their work. The licensor cannot revoke these freedoms as long as you follow the license terms. Learn the details at the License policy.
How to Cite
