Development of size-tunable polymeric nanoparticles for drug delivery applications
DOI:
https://doi.org/10.35898/ghmj-12113Keywords:
Drug delivery, Polymeric nanoparticles, Tunable size of nanoparticlesAbstract
Background: Poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) have been widely used in drug delivery applications because of its excellent properties such as biocompatibility, biodegradability along with its abilities to deliver hydrophobic drugs, increase drug bioavailability, and improve drug absorption to targeted cells in both oral and parenteral administrations. The PLGA NPs can be synthesized using emulsion solvent evaporation method. Each parameter during synthesis play a role in formation of nanoparticles and could affect to form different NP sizes which is an important factor for successful development of drug delivery system.
Aims: The aim of this study is to prepare different sizes of PLGA NPs by investigation of four factors (molecular weight (MW) of PLGA, emulsifier concentrations, organic solvent type and power of ultrasonication) that involve in PLGA nanoparticle synthesis.
Methods: PLGA nanoparticles were prepared by emulsion solvent evaporation method. Size and size distribution were analyzed by dynamic light scattering and polydispersity index (PdI).
Results: The effect of four parameters: PLGA MW, emulsifier concentrations, solvent types, and amplitude of ultrasonication on PLGA NPs preparation were evaluated. Changing one parameter results in different sizes of PLGA NPs varied from 150-300 nm. PdI which is an indicator for determination of size distribution of NPs are also varied with overall value less than 0.2.
Conclusion: MW of PLGA polymer, emulsifier concentration, type of organic solvent and power of ultrasonication affect the size and size distribution of PLGA NPs.
Submitted: 16 October 2017, Accepted: 27 October 2017.
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Tabatabaei Mirakabad FSN-K, Kazem; Akbarzadeh, Abolfazl; Yamchi, Mohammad Rahmati; Milani, Mortaza; Zarghami, Nosratollah; Zeighamian, Vahideh; Rahimzadeh, Amirbahman; Alimohammadi, Somayeh; Hanifehpour, Younes; Joo, Sang Woo. PLGA-based nanoparticles as cancer drug delivery systems. Asian Pacific Journal of Cancer Prevention. 2014;15(2):517-35.
Dinarvand R, Sepehri N, Manoochehri S, Rouhani H, Atyabi F. Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents. International Journal of Nanomedicine. 2011;6:877-95.
Marguet M, Bonduelle C, Lecommandoux S. Multicompartmentalized polymeric systems: towards biomimetic cellular structure and function. Chemical Society Reviews. 2013;42(2):512-29.
Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and Surfaces B: Biointerfaces. 2010;75(1):1-18.
Kocbek P, Obermajer N, Cegnar M, Kos J, Kristl J. Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. Journal of Controlled Release. 2007;120(1):18-26.
Yin Win K, Feng S-S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005;26(15):2713-22.
Zhou S, Deng X, Li X, Jia W, Liu L. Synthesis and characterization of biodegradable low molecular weight aliphatic polyesters and their use in protein-delivery systems. Journal of Applied Polymer Science. 2004;91(3):1848-56.
Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V. PLGA-based nanoparticles: An overview of biomedical applications. Journal of Controlled Release. 2012;161(2):505-22.
Lü J-M, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, et al. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Review of Molecular Diagnostics. 2009;9(4):325-41.
Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles. Molecular Pharmaceutics. 2008;5(4):505-15.
Singh R, Lillard JW. Nanoparticle-based targeted drug delivery. Experimental and molecular pathology. 2009;86(3):215-23.
Redhead HM, Davis SS, Illum L. Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. Journal of Controlled Release. 2001;70(3):353-63.
Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, et al. Polymer degradation and in vitro release of a model protein from poly(d,l-lactide-co-glycolide) nano- and microparticles. Journal of Controlled Release. 2003;92(1):173-87.
Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Ipe BI, et al. Renal Clearance of Nanoparticles. Nature biotechnology. 2007;25(10):1165-70.
Montalvo-Ortiz BL, Sosa B, Griebenow K. Improved Enzyme Activity and Stability in Polymer Microspheres by Encapsulation of Protein Nanospheres. AAPS PharmSciTech. 2012;13(2):632-6.
Morales-Cruz M, Flores-Fernández GM, Morales-Cruz M, Orellano EA, Rodriguez-Martinez JA, Ruiz M, et al. Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres. Results in Pharma Sciences. 2012;2:79-85.
Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MNV. Estradiol loaded PLGA nanoparticles for oral administration: Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. Journal of Controlled Release. 2007;119(1):77-85.
Dutschk V, Chen J, Petzold G, Vogel R, Clausse D, Ravera F, et al. The role of emulsifier in stabilization of emulsions containing colloidal alumina particles. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2012;413(Supplement C):239-47.
Sahoo SK, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. Journal of Controlled Release. 2002;82(1):105-14.
McCall RL, Sirianni RW. PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS. Journal of Visualized Experiments : JoVE. 2013(82):51015.
Bilati U, Allémann E, Doelker E. Sonication Parameters for the Preparation of Biodegradable Nanocapsulesof Controlled Size by the Double Emulsion Method. Pharmaceutical Development and Technology. 2003;8(1):1-9.
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