COMPARISON OF EFFECTIVENESS BETWEEN CELERY JUICE (Apium graveolens L.) AND 2% MICONAZOLE TOWARDS THE GROWTH OF Malassezia furfur

Authors

  • Ronaa Hammada Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia
  • Witri Pratiwi Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia
  • Shofa Nur Fauzah Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia
  • Donny Nauphar Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia
  • Amanah Amanah Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia

Keywords:

Apium graveolens L., squeezed celery juice, Malassezia furfur, Miconazole 2%

Abstract

Introduction: Pityriasis versicolor is caused by the fungi Malassezia furfur with a worldwide prevalence of 50%, including tropical countries, second only to dermatitis in Indonesia. Pityriasis versicolor is difficult to treat and requires long-term treatment. The disease has high recurrence risk and may cause drug resistance. 2% Miconazole is known to have long-term side effects; therefore, alternative treatment is needed. Several studies suggested that celery (Apium graveolens L.) contains active substances with anti-fungal properties. This paper aims to investigate the comparison of effectiveness between celery juice and 2% Miconazole towards the growth of Malassezia furfur.

Methods: This is an in-vitro experimental study with post-test only control group design. The subjects were split into 5 groups which were given celery juice in 10% DMSO with the concentration of 10%, 20%, 30%, 40%, and 50%. A negative control group was given only 10% DMSO and the positive control group was given 2% Miconazole. The data were then analyzed using Kruskall-Wallis followed by Mann-Whitney test.

Results: The Kruskall-Wallis test showed all concentration of celery juice had antifungal effect with p=0.000 (p<0.05) and were effective in inhibiting the growth of Malassezia furfur. The Mann-Whitney test showed that the 50% celery concentration was as effective as 2% Miconazole in inhibiting the growth of Malassezia furfur (p=0.495).

Conclusion: Celery juice (Apium graveolens L.) was effective in inhibiting the growth of Malassezia furfur with 50% concentration as the most effective concentration.

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Published

2018-08-02

How to Cite

Hammada, R., Pratiwi, W., Fauzah, S. N. ., Nauphar, D., & Amanah, A. (2018). COMPARISON OF EFFECTIVENESS BETWEEN CELERY JUICE (Apium graveolens L.) AND 2% MICONAZOLE TOWARDS THE GROWTH OF Malassezia furfur. Proceedings of the International Conference on Applied Science and Health, (3), 73–77. Retrieved from https://publications.inschool.id/index.php/icash/article/view/757

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