• Zubaeda Zubaeda Master of Applied Science in Midwifery, Poltekkes Kemenkes emarang, Semarang, Indonesia
  • Nur Khafidhoh Master of Applied Science in Midwifery, Poltekkes Kemenkes emarang, Semarang, Indonesia


Background: The frequency of using the antibiotics and antifungals as a treatment of leucorrhea may cause the bacterial and fungal resistance. Therefore, a treatment is not always optimal and sometimes leads the infection to be worsen. The herbal medicine is needed as an alternative treatment. This study aims to examine the effectiveness of using various herbal medicine in the management of leucorrhea.

Methodology: The literature review was conducted in several electronic databases i.e., Google Scholar, Science Direct, and PubMed. The protocol for this study was PRISMA. The keywords such as "herbal medicine" and "leucorrhea" or "vaginal infection" were used to select the literatures. This study only selected the studies conducted during 2000 to 2019, presented in English and used clinical trial research design.

Results: This study obtained 10 of 5184 total publications from electronic databases. The publication about herbal medicine for leucorrhea, both of herbal medicine and placebo, herbal medicine compared to conventional medicine and herbal medicine combined with conventional medicine showed that herbal medicine could reduce the symptoms and complaints of leucorrhea which had the ability to be an antimicrobial agent. In contrast, 2 studies revealed the side effects of herbal medicine, i.e., irritation,
vomiting, and dry vagina.

Conclusion: Herbal medicine was effective as a treatment of leucorrhea and had the prospect to develop as a complementary therapy for treating the leucorrhea.

Keywords: Leucorrhea, complementary therapy, herbal medicine


Ilmiawati H. Pengetahuan Personal Hygiene Remaja Putri pada Kasus Keputihan (Young Woman Personal Hygiene Knowledge in Leucorrhea Cases). J Biometrika dan Kependud. 2014;5(1):43–51.

Kaur J, Kapoor AK. Perceptions and Knowledge about Leukorrhea in a Slum Dwelling South Asian Community. J Fam Reprod Heal. 2014;8(1):45–52.

Liu C, Zhang Y, Kong S, Tsui I, Yu Y, Han F. Applications and Therapeutic Actions of Complementary and Alternative Medicine for Women with Genital Infection. Evidence-Based Complement Altern Med. 2014;

Tjitraresmi AMI, Agung SRI, Kusuma F, Rusmiati D. Cabbage Leaf Extract ( Brassica Oleracea Var . Capitata Alba ) As A Herbal Medicine For Leukorrhea. Asian J Pharm Clin Res. 2017;

Abid M, Kumar K, Ali S, Chandra P. Assessment of Leucorrhea diseases in female students. J Sci Innov Res. 2016;5(4):116–8.

Darma M, Yusran S, Fachlevy AF. Hubungan pengetahuan, vulva hygiene, stres , dan pola makan dengan kejadian infeksi flour albus pada remaja siswi sma negeri 6 kendari 2017 (The Relation Between Knowledge, Vulva Hygiene, Stress and Diet With The Insident of Flour Albus in SMP 6 Kendari 2017). J Imiah Mhs Kesehat Masy. 2017;2(6):1–9.

Sakineh M, Alizadeh, Charandabi, Zahra M, Azizeh F, Khalili, et al. E ffect of H ypericum perforatum L . compared with

metronidazole in bacterial vaginosis : a double-blind randomized trial. Asian Pac J Trop Biomed. 2014;4(11):896–902.

Morschhäuser J. The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal

pathogen. J Microbiol. 2016;54(3):192–201.

Kothavade RJ, Kura MM, Valand AG, Panthaki MH. Candida tropicalis : its prevalence , pathogenicity and increasing resistance to

fluconazole. J Med Microbiol. 2010;(2010):873–80.

Sholekhudin M. Buku Obat Sehari - Hari. Jakarta: PT Elex Media Komputindo; 2014. 179 p.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-

analysis protocols (PRISMA-P) 2015: elaboration and explanation. Res METHODS Report [Internet]. 2015;7647(January):1–25.

Available from:

Praveen C. Role of Lukol Syrup in Relieving the Symptoms Associated with Leucorrhoea : A Randomized , Double Blind Placebo

Controlled Clinical Study. Int J Sci Res. 2015;4(10):1764–9.

Khan M, Shameem I, Imran S, Begum IJ, Unani MO, Unani MO. Effect of Gule Dhawa and Mocharas in Sailan al Rahim : A

randomized controlled trial. Int J Adv Sci Res. 2017;2(3):38–42.

Abdali K, Jahed L, Amooee S, Zarshenas M, Tabatabaee H, Bekhradi R. Comparison of the Effect of Vaginal Zataria multiflora

Cream and Oral Metronidazole Pill on Results of Treatments for Vaginal Infections including Trichomoniasis and Bacterial

Vaginosis in Women of Reproductive Age. Biomed Res Int. 2015;

Tara F, Zand-Kargar Z, Rajabi O, Berenji F, Akhlaghi F, Shakeri MT, et al. The Effects of Ozonated Olive Oil and Clotrimazole

Cream for Treatment of Vulvovaginal Candidiasis. Altern Ther. 2016;22(4):44–9.

Saghafi N, Karjalian M, Ghazanfarpour M, Rakhshandeh H, Mirteimouri M, Khadivzadeh T, et al. The effect of a vaginal suppository formulation of dill ( Anethum graveolens ) in comparison to clotrimazole vaginal tablet on the treatment of vulvovaginal candidiasis. J Obstet Gynaecol (Lahore) [Internet]. 2018;0(0):1–4. Available from:

Darvishi M, Jahdi F, Hamzegardeshi Z, Goodarzi S, Vahedi M. The Comparison of Vaginal Cream of Mixing Yogurt , Honey and

Clotrimazole on Symptoms of Vaginal Candidiasis. Glob J Health Sci. 2015;7(6):108–16.

Masoudi M, Miraj S, Rafieian-kopaei M. Comparison of the Effects of Myrtus Communis L , Berberis Vulgaris and Metronidazole

Vaginal Gel alone for the Treatment of Bacterial Vaginosis. J Clin Diagnostic Res. 2016;10(3):3–6.

Masoudi M, Kopaei MR, Miraj S. A comparison of the efficacy of metronidazole vaginal gel and Myrtus ( Myrtus communis ) extract combination and metronidazole vaginal gel alone in the treatment of recurrent bacterial vaginosis. Avicenna J Phytomedicine.


Zare A, Moshfeghy Z, Zarshenas MM, Namavar B, Akbarzadeh M, Sayadi M. Quercus Brantii Lindl. Vaginal Cream versus Placebo

on Bacterial Vaginosis: a Randomized Clinical Trial. J Herb Med [Internet]. 2018; Available from:

Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5(47):1–15.

Awodele O, Amagon KI, Wannang NN, Aguiyi JC. Traditional Medicine Policy and Regulation in Nigeria : An Index of Herbal

Medicine Safety. Curr Drugs Saf. 2014;9:16–22.

Parthik P, Patel NM, Patel PM. WHO Guidelines On Quality Control Of Herbal Medicines. Int J Res Ayurveda Pharmachy.




How to Cite

Zubaeda, Z., & Khafidhoh, N. (2019). COULD HERBAL MEDICINE BE A COMPLEMENTARY THERAPY IN LEUCORRHEA TREATMENT AND CARE?. Proceedings of the International Conference on Applied Science and Health, (4), 621–627. Retrieved from