• Lia Arian Apriani Master of Applied Science in Midwifery, Poltekkes Kemenkes Semarang, Semarang, Indonesia
  • Ida Ariyanti Master of Applied Science in Midwifery, Poltekkes Kemenkes Semarang, Semarang, Indonesia


Background: Seaweed as one of the natural resources has many potential bioactive ingredients. One of them is Phaeophyceae which shows the highest antioxidant activity among other seaweed. Sargassum sp has many potential bioactive ingredients in the pharmaceutical field which has been supported by several scientific studies. This study aims to expose all information related to abilities Sargassum sp as an antioxidant for endothelial cell protection in preeclampsia in a comprehensive and systematic

Methods: This study was a systematic review that used the prism protocol. Data obtained from Electronic databases Science Direct, Springer, DOAJ, NCBI and Google Scholar that published between 2009 and 2019. By using keywords such as an antioxidants of Sargassum sp, preeclampsia and antioxidants, as well as antioxidants and endothelial cells to find the relevant journal.

Results: The search found 963 articles, of which 215 articles were included in the inclusion and exlusion criteria. The final results obtained 8 articles that are suitable for this literature review. Majority of studies used the same method namely experimental, 3 other studies uses meta-analysis randomized controlled trials, and a case-control study. Analysis of the studies found out that Sargassum sp contains phenolic compounds which function as antioxidants in fighting free radicals and as protection against
endothelial cells in preeclampsia.

Conclusion: Sargassum sp is proven to have the value of high antioxidant effect that is able to fight free radicals and is able to protect endothelial cells in preeclampsia. Therefore, this study is presented to assist researchers in planning their future studies related to seaweed in preventing preeclampsia in the fields of obstetrics and gynecology and with the hope of potential future drug development.

Keywords: Sargassum sp, Antioxidants, Endothelial Cells, Preeclampsia


Anonymous. Ministry of Health of the Republic of Indonesia. the Indonesian Health Profile. 2016.

Indonesia PK. the Indonesian Health Profile. 2017. 2018;

Sargowo D. Endothelial Dysfunction. First Edition. Wiranata, Wendi; Anggraini L, editor. Malang: UB Press; 2015. 141–152 p.

Available from: http://www.ubpress.ub.ac.id

Subandrate, Faisal M, Anggarini WN. The Role of Oxidative Stress in Preeclampsia. Cdk-244. 2017;44(5):353–5.

Keman K. Pathomechanism of Recent Preeclampsia. First Edition. Malang: Brawijaya University Press; 2014. 1 p.

Vadlapudi V et al. Antioxidant Activities of Marine Algae : A Review. Int J Recent Sci Res. 2012;99–102.

Liu Y, Lai Q, Dong C, Sun F, Wang L, Li G, et al. Phylogenetic Diversity of the Bacillus pumilus Group and the Marine Ecotype

Revealed by Multilocus Sequence Analysis. Driks A, editor. PLoS One [Internet]. 2013 Nov 11 [cited 2019 Mar 3];8(11):e80097.

Available from: https://dx.plos.org/10.1371/journal.pone.0080097

Kelman D, Posner EK, McDermid KJ, Tabandera NK, Wright PR, Wright AD. Antioxidant Activity of Hawaiian Marine Algae. Mar

Drugs [Internet]. 2012 Feb 15 [cited 2019 Mar 3];10(12):403–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22412808

Yudiati E, Isnansetyo A. Fish & Shell fi sh Immunology Innate immune-stimulating and immune genes up-regulating activities of three types of alginate from Sargassum siliquosum in Paci fi c white shrimp , Litopenaeus vannamei. Fish Shellfish Immunol

[Internet]. 2016;54:46–53. Available from: http://dx.doi.org/10.1016/j.fsi.2016.03.022

Prabowo A, Budhiyanti SA. ON THE TEMPERATURE OF ROOMS Sargassum sp . Extract as an Antioxidant for Fish

Oil Emulsion System During Storage at Room Temperature. 2013;143–50.

Bhaigyabati T, Kirthika T, Shiny K, Usha K. Phytochemical screening and antioxidant activity of various extracts of Sargassum

muticum. Vol. 3, IJPRD. 2011. 25–30 p.

Boonchum W, Peerapornpisal Y, Kanjanapothi D, Pekkoh J, Pumas C, Jamjai U, et al. Antioxidant activity of some seaweed from

the Gulf of Thailand. Int J Agric Biol. 2011;13(1):95–9.

Gazali M, Nurjanah N, Zamani NP. The Exploration of Bioactive Compound to Brown Algae Sargassum sp. Agardh as Antioxidant

from West of Aceh Coastal. Journal of Indonesian Fisheries Products Processing. 2018;21(1):167.

Chitra R, Ali M S, Anuradha V, Shantha M. Antioxidant activity of polysaccharide from Sargassum sp. IOSR J Pharm. 2018;8(8):24–

Cong Q, Chen H, Liao W, Xiao F, Wang P, Qin Y, et al. Structural characterization and effect on anti-angiogenic activity of a

fucoidan from Sargassum fusiforme. Carbohydr Polym [Internet]. 2016 Jan [cited 2019 Jun 25];136:899–907. Available from:


Gwon W-G, Joung E-J, Kwon M-S, Lim S-J, Utsuki T, Kim H-R. Sargachromenol protects against vascular inflammation by

preventing TNF-α-induced monocyte adhesion to primary endothelial cells via inhibition of NF-κB activation. Int Immunopharmacol

[Internet]. 2017 Jan [cited 2019 Jun 25];42:81–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27902962

Taravati A, Tohidi F. Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia. Taiwan J Obstet

Gynecol [Internet]. 2018 Dec 1 [cited 2019 Apr 29];57(6):779–90. Available from:


Tenório MB, Ferreira RC, Moura FA, Bueno NB, Goulart MOF, Oliveira ACM. Oral antioxidant therapy for prevention and

treatment of preeclampsia: Meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis [Internet]. 2018 Sep 1 [cited

Apr 29];28(9):865–76. Available from: https://www.sciencedirect.com/science/article/pii/S093947531830190X

Cohen JM, Kramer MS, Platt RW, Basso O, Evans RW, Kahn SR. The association between maternal antioxidant levels in midpregnancy and preeclampsia. Am J Obstet Gynecol [Internet]. 2015 Nov 1 [cited 2019 Apr 29];213(5):695.e1-695.e13. Available

from: https://www.sciencedirect.com/science/article/pii/S0002937815007772

Roberts JM, Speer P. Antioxidant therapy to prevent preeclampsia. Semin Nephrol [Internet]. 2004 Nov 1 [cited 2019 Apr

;24(6):557–64. Available from: https://www.sciencedirect.com/science/article/pii/S0270929504001263

Keman K. Pathomechanism of Recent Preeclampsia. First Edition. Malang: Brawijaya University Press; 2014. Available from:


Cunningham F et al. Obstetric Williams. 23rd ed. Jakarta: Jakarta; 2010.

Leslie K, Thilaganathan B, Papageorghiou A. Early prediction and prevention of pre-eclampsia. Best Pract Res Clin Obstet Gynaecol

[Internet]. 2011 Jun [cited 2019 Mar 3];25(3):343–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21376671

Niki E. Lipid peroxidation: Physiological levels and dual biological effects. Free Radic Biol Med [Internet]. 2009 Sep 1 [cited 2019

Mar 3];47(5):469–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19500666

Werdhasari A. The Role of Antioxidants for Health. 2014;

Ye H, Zhou C, Sun Y, Zhang X, Liu J, Hu Q, et al. Antioxidant activities in vitro of ethanol extract from brown seaweed Sargassum

pallidum. Eur Food Res Technol [Internet]. 2009 Nov 25 [cited 2019 Mar 3];230(1):101–9. Available from:


Sargowo D. ENDOTEL Dysfunction. First Edition. Malang: Brawijaya University Press; 2015. 142 p. Available from:

https://books.google.co.id/books?id=t0JRDwAAQBAJ&printsec=frontcover&hl=id&source=gbs_ge_summary_r&cad=0#v=onepage&q=disfungsi endotel pada preeklampsia&f=false

Yuslianti ER. Introduction to Free Radicals and Antioxidants.First Edition. Rahmadhani, Herlambang; Sartono CM, editor.

Yogyakarta: Deepublish CV Budi Utama; 2018. 109 p. Available from: www.penerbitdeepublish.co.id

Astutik P, Adriani M, Wirjatmadi B. Superoxide (O2-), nitric oxide (NO) and fat intake in hypertensive and non-hypertensive

patients. J. Nutrition Indonesia. 2014;3(1):1–6. Available from: ejournal.undip.ac.id/index.php/jgi/article/download/8744/8465

Rastini EK, Widodo MA, Rohman MS. The Effect of Morinda citrifolia L. Extract on Activation of NF-β and Protein Expression

(TNF-α, ICAM-1) in Culture Endothelial cells (HUVECs) Exposed to Ox-LDL. 2010;1(1):48–55.

Suhatri S, Helmi A, Hadira Fitri Linda I. PROTECTIVE EFFECTS OF SURIAN LEAF EXTRACT (Toona sureni (Blume) Merr.) AGAINST DISORDER FUNCTIONS OF BLOOD VESSEL ENDOTEL CELLS. 2009 [cited 2019 Mar 3]; Available from:


Sargassum C, Sedjati S, Santosa A, Supriyantini E. Antioxidant Activities and Macroalgae Phenolic Compounds.


Samee H, Li Z, Lin H, Khalid J, Guo Y. Anti-allergic effects of ethanol extracts from brown seaweeds. J Zhejiang Univ Sci B

[Internet]. 2009 Feb 18 [cited 2019 Mar 3];10(2):147–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19235274

Wang T, Jónsdóttir R, Ólafsdóttir G. Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds. Food Chem [Internet]. 2009 Sep [cited 2019 Mar 3];116(1):240–8. Available from:


Hong Yu L, Bin W, Chun Guang Y, You le Q, Chuan ling S. Evaluation of antioxidant activities of five selected brown seaweeds

from China. J Med Plants Res [Internet]. 2010 Dec 4 [cited 2019 Mar 3];4(23):2557–65. Available from: http://academicjournals.org/journal/JMPR/articleabstract/8F2735321787

Vijayabaskar P, Vaseela N, Thirumaran G. Potential antibacterial and antioxidant properties of a sulfated polysaccharide from the brown marine algae Sargassum swartzii. Chin J Nat Med [Internet]. 2012;10(6):421–8. Available from: http://dx.doi.org/10.1016/S1875-5364(12)60082-X

Moubayed NMS, Jawad H, Houri A, Khulaifi MM Al, Farraj DA Al. Antimicrobial , antioxidant properties and chemical composition of seaweeds collected from Saudi Arabia ( Red Sea and Arabian Gulf ). Saudi J Biol Sci [Internet]. 2017;24(1):162–9. Available from: http://dx.doi.org/10.1016/j.sjbs.2016.05.018



How to Cite

Apriani, L. A., & Ariyanti, I. (2019). EFFECTIVENESS OF BROWN SEAWEED (Sargassum sp.) AS NATURAL ANTIOXIDANT FOR ENDOTHELIAL CELL PROTECTION IN PREECLAMPSIA: A LITERATURE REVIEW. Proceedings of the International Conference on Applied Science and Health, (4), 535–544. Retrieved from https://publications.inschool.id/index.php/icash/article/view/674