IS THE MULTIPLE MICRONUTRIENTS BETTER TO REDUCE ANEMIA IN PREGNANCY COMPARED TO IRON- FOLATE ACID SUPLEMENTATION? A SYSTEMATIC REVIEW

Authors

  • Beniqna Maharani Besmaya Master of Applied Science in Midwifery, Poltekkes Kemenkes Semarang, Semarang, Indonesia
  • Runjati Runjati Master of Applied Science in Midwifery, Poltekkes Kemenkes Semarang, Semarang, Indonesia
  • Ari Suwondo Master of Applied Science in Midwifery, Poltekkes Kemenkes Semarang, Semarang, Indonesia
  • Siti Nurharisah Master of Applied Science in Midwifery, Poltekkes Kemenkes Semarang, Semarang, Indonesia

Abstract

Background: Prevalence of anemia continues to increase among pregnant women in Indonesia. The micronutrients that are needed to reduce the anemia is still lacking to be accessed by pregnant women. This study aims to analyze the effectiveness of multiple micronutrients (MMN) compared to the iron-folic acid to reduce the incidence of anemia among pregnant women.

Methods: Systematic review was used in this study using the electronic databases Google Scholar, Science Direct, and PubMed. The articles included in this study were published in 2009-2018 and were written in English language.

Results: In total, 380 papers were identified and six articles were included in this study. Study found that the MMN and iron-folic acid had the same effect in influencing the anemia status among pregnant women. However, the MMN had a potential to increase the average of body weight, to reduce the incidence of low birth weight (LBW) and preterm birth among pregnant women.

Conclusions: The effectiveness of multi micronutrients in pregnant women is as good as iron-folic acid in reducing the anemia during pregnancy. Further studies need to be conducted to see the effects of MMN on pregnant women by considering other factors such as maternal nutritional status, gestational age, and duration of supplementation

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References

World Health Organization, "Anaemia Policy Brief,” Glob. Nutr. Targets 2025, vol. 2, no. WHO/NMH/NHD/14.4, p. 8, 2014.

J. B. Sharma and M. Shankar, "Anemia in Pregnancy . PREVALENCE OF ANEMIA IN,” vol. 23, no. 4, pp. 253–260, 2010.

Kemenkes RI, "Basic Health Research Basic Health Research,” pp. 1–359, 2013.

R. Gangopadhyay, M. Karoshi, and L. Keith, "Anemia and pregnancy: A link to maternal chronic diseases,” Int. J. Gynecol. Obstet., vol. 115, no. SUPPL. 1, pp. S11–S15, 2011.

B. A. Haider, M. Y. Yakoob, and Z. A. Bhutta, "Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes,” BMC Public Health, vol. 11, no. SUPPL. 3, 2011.

D. I. Sektor and P. Dan, "Profil Kesehatan Provinsi Jawa Tengah Tahun 2017,” vol. 3511351, no. 24, 2017.

N. Aranda, B. Ribot, E. Garcia, F. E. Viteri, and V. Arija, "Pre-pregnancy iron reserves, iron supplementation during pregnancy, and birth weight,” Early Hum. Dev., vol. 87, no. 12, pp. 791–797, 2011.

K. K. R. B. P. dan P. Kesehatan, "Hasil Utama Riskesdas 2018,” 2018.

W. Septiani, "Pelaksanaan Program Pemberian Tablet Zat Besi (Fe) pada Ibu Hamil,” J. midwifery Sci., vol. 1, no. 2, pp. 86–92, 2017.

A. D. Gernand, K. J. Schulze, C. P. Stewart, K. P. West, and P. Christian, "Micronutrient deficiencies in pregnancy worldwide: Health effects and prevention,” Nat. Rev. Endocrinol., vol. 12, no. 5, pp. 274–289, 2016.

C. M. Glosz, A. A. Schaffner, S. K. Reaves, M. J. Manary, and P. C. Papathakis, "Effect of nutritional interventions on micronutrient status in pregnant malawian women with moderate malnutrition: A randomized, controlled trial,” Nutrients, vol. 10, no. 7, pp. 1–14, 2018.

L. í…. Persson et al., "Effects of Prenatal Micronutrient and Early Food Supplementation on Maternal Hemoglobin, Birth Weight, and Infant Mortality Among Children in Bangladesh,” Jama, vol. 307, no. 19, 2012.

C. N, A. A, H. SM, and Z. SH, "Relative efficacy of micronutrient powders versus iron-folic acid tablets in controlling anemia in women in the second trimester of pregnancy.,” Food Nutr. Bull., vol. 33, no. 2, pp. 142–149, 2012.

Z. Mei, M. E. Jefferds, S. Namaste, P. S. Suchdev, and R. C. Flores-Ayala, "Monitoring and surveillance for multiple micronutrient supplements in pregnancy,” Matern. Child Nutr., vol. 14, no. April, pp. 1–9, 2018.

Y. Kang et al., "Multi-micronutrient supplementation during pregnancy for prevention of maternal anaemia and adverse birth outcomes in a high-altitude area: A prospective cohort study in rural Tibet of China,” Br. J. Nutr., vol. 118, no. 6, pp. 431–440, 2017.

A. Dilawar, G. Qureshi, U. Khurram, R. Khan, and S. Malik, "Original Article Effect of Iron With Mineral and Multivitamin Supplementation on Transferrin Saturation Index in Iron Deficiency Anemia During Pregnancy,” Pak J Physiol, vol. 8, no. 1, pp. 19–22, 2012.

Sunawang, B. Utomo, A. Hidayat, Kusharisupeni, and Subarkah, "Preventing low birthweight through maternal multiple micronutrient supplementation: A cluster-randomized, controlled trial in lndramayu, West Java,” Food Nutr. Bull., vol. 30, no. 4 SUPPL., pp. 488–495, 2009.

L. H. Allen et al., "Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy,” Food Nutr. Bull., vol. 30, no. 4 SUPPL., pp. 527–532, 2009.

Z. A. Bhutta, A. Imdad, U. Ramakrishnan, and R. Martorell, "Is it time to replace iron folate supplements in pregnancy with multiple micronutrients?,” Paediatr. Perinat. Epidemiol., vol. 26, no. SUPPL. 1, pp. 27–35, 2012.

W. Y.F. et al., "Impact of periconceptional multi-micronutrient supplementation on gestation: a population-based study.,” Biomed. Environ. Sci., vol. 26, no. 1, pp. 23–31, 2013.

S. K. Sebayang, M. J. Dibley, P. Kelly, A. V. Shankar, and A. H. Shankar, "Modifying effect of maternal nutritional status on the impact of maternal multiple micronutrient supplementation on birthweight in Indonesia,” Eur. J. Clin. Nutr., vol. 65, no. 10, pp. 1110–1117, 2011.

R. L. Bailey, K. P. West, and R. E. Black, "The epidemiology of global micronutrient deficiencies,” Ann. Nutr. Metab., vol. 66, no. suppl 2, pp. 22–33, 2015.

Published

2019-08-25

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How to Cite

IS THE MULTIPLE MICRONUTRIENTS BETTER TO REDUCE ANEMIA IN PREGNANCY COMPARED TO IRON- FOLATE ACID SUPLEMENTATION? A SYSTEMATIC REVIEW. (2019). Proceedings of the International Conference on Applied Science and Health, 4, 419-432. https://publications.inschool.id/index.php/icash/article/view/662