SYSTEMATIC REVIEW METABOLIC DISRUPTION IN GESTATIONAL HYPERTENSION DISORDER
Background: Gestational hypertension is one of the diseases responsible for increased morbidity and 18% of maternal deaths in the world. Gestational hypertension has complex causes and symptoms, so pathogenesis is difficult to determine. Complications of gestational hypertension will cause Preeclampsia. This study aims to explain the metabolic disorders experimented by women with gestational hypertension. This description can be used as an early detection tool for hypertension so that complications can be prevented.
Methodology: Searching articles for this research is done by searching in the google scholar, science direct and PubMed databases. Only full text and written by english will be included in this study. The keyword that is used “Risk Factor” or “Metabolic” and “Gestational Hypertension” or “Blood Pressure” or “Pregnancy Hypertension” with the year limit between 2009 – 2019. A systematic review of PRISMA was used in this study. The study focused on the discussion about gestational hypertension in pregnant women.
Results: 12 research articles were foundit is known that pregnant women with gestational hypertension have serum calcium, magnesium, nitric oxide, vitamin D, cobalt and iodine which tend to be lower than normal pregnant women. Whereas cadmium levels tend to be high can stimulate oxidative stress which is able to worsen the condition leading to preeclampsia.
Conclusion: Health checks on pregnant women can be used as a basis for screening and treatment. Methods of checking calcium levels that allow as medium for screening in detecting the severity of hypertension and predicting disease risk.
Lalenoh, C.D. Preeklampsia Berat dan Eklampsia : Tatalaksana Anestesia Perioperatif. Severe (Preeclampsia and Eclampsia : Management of Perioperative Anesthesia). Yogyakarta: depublish; 2018. (Indonesian)
Souza, J. P., Gülmezoglu, A. M., Vogel, J., Carroli, G., Lumbiganon, P., Qureshi, Z., et.al. Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study. The Lancet. (2013) 381(9879), 1747–1755.
Alves, E., Azevedo, A., Rodrigues, T., Santos, A. C., & Barros, H. Impact of risk factors on hypertensive disorders in pregnancy, in primiparae and multiparae. Annals of Human Biology, 40(5). (2013);377–384.
Ephraim, R. K. D., Osakunor, D. N. M., Denkyira, S. W., Eshun, H., Amoah, S., & Anto, E. O. Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana. BMC Pregnancy and Childbirth. (2014); 14(1).
Gasnier, R., Valério, E. G., Vettorazzi, J., Martins-Costa, S. H., Barros, E. G., & Ramos, J. G. L. Calcium-to-creatinine ratio in pregnancy-induced hypertension. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. (2012); 2(1), 59–64.
Hofmeyr, G. J. Betran, A. P. Madliki, M. S. Cormick G, Munjanja, S. P, Fawcus, S. Mose, S. Hall, D. Ciganda, A. Seuc, A. H. Et al. Prepregnancy and early pregnancy calcium supplementation among women at high risk of pre-eclampsia: a multicentre, double-blind, randomized, placebo-controlled trial. Lancet. (2019); 393: 330–39
Liang, C., Wang, J., Xia, X., Wang, Q., Li, Z., Tao, R., et. al. Serum cobalt status during pregnancy and the risks of pregnancy-induced hypertension syndrome: A prospective birth cohort study. Journal of Trace Elements in Medicine and Biology;(2018). 46, 39–45.
Liu, H., Xia, W., Xu, S., Zhang, B., Lu, B., Huang, Z., et. al. Cadmium body burden and pregnancy-induced hypertension. International Journal of Hygiene and Environmental Health. (2018).; 221(2), 246–251.
Zeng Y, Li M, Chen Y, Wang S. Homocysteine, endothelin-1 and nitric oxide in patients with hypertensive disorders complicating pregnancy. International Journal of Clinical Experimental Pathology. ( 2015);8(11): 15275–15279.
Van Weert, B., van den Berg, D., Hrudey, E. J., Oostvogels, A. J. J. M., de Miranda, E., & Vrijkotte, T. G. M. Is first-trimester vitamin D status in nulliparous women associated with pregnancy-related hypertensive disorders? Midwifery.; (2016). 34, 117–122.
Vidal, Z. E. O., Rufino, S. C., Tlaxcalteco, E. H., Trejo, C. H., Campos, R. M., Meza, M. N., et. al. Oxidative Stress Increased in Pregnant Women with Iodine Deficiency. Biological Trace Element Research (2014). ; 157(3), 211–217.
Moraes, D., Munhoz, T. P., Pinheiro da Costa, B. E., Hentschke, M. R., Sontag, F., Silveira Lucas, L., et. al. Immature platelet fraction in hypertensive pregnancy. Platelets. (2015). ;27(4), 333–337.
Kattah, A. G., & Garovic, V. D. The Management of Hypertension in Pregnancy. Advances in Chronic Kidney Disease. (2013). ; 20(3), 229–239.
Kumar, N., & Singh, A. K. Maternal serum uric acid and calcium as predictors of hypertensive disorder of pregnancy: A case-control study. Taiwanese Journal of Obstetrics and Gynecology. (2019). ; 58(2), 244–250.
McGrowder, D., Williams, A., Gordon, L., Crawford, T., Lindo, R. A., Irving, R., Hamilton, M., Fraser, Y. T.P., Hypocalciuria in pre-eclampsia and gestational hypertension due to decreased fractional excretion of calcium. Archives of medical science. (2009); vol.5 Iss. 1. 80
Rufino, S.C., Meza, M.N., Solís, P.G., Rosas, I.X., Helguera, O.A., Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease. Nutrition Hospitalaria. (2017); 34(3):661-666.
Medici, M., Korevaar, T. I. M., Schalekamp-Timmermans, S., Gaillard, R., de Rijke, Y. B., Visser, W. E., et. al. Maternal Early-Pregnancy Thyroid Function Is Associated With Subsequent Hypertensive Disorders of Pregnancy: The Generation R Study. The Journal of Clinical Endocrinology & Metabolism. (2014). 99(12), E2591–E2598.
Roberts, J. M., & Bell, M. J. If we know so much about preeclampsia, why haven’t we cured the disease? Journal of Reproductive Immunology. (2013). ; 99(1-2)
Gudnadóttir, T. A., Bateman, B. T., Hernádez-Díaz, S., Luque-Fernandez, M. A., Valdimarsdottir, U., & Zoega, H. Body Mass Index, Smoking and Hypertensive Disorders during Pregnancy: A Population Based Case-Control Study. PLOS ONE,. (2016);11(3), e0152187.