Potential of Carrageenans in Foods and Medical Applications

Authors

  • Hafizh Muhammad Noor Mahidol University

DOI:

https://doi.org/10.35898/ghmj-22188

Abstract

Background: Carrageenans, the polysaccharides obtained by extraction of certain species of red seaweeds (Rhodophyceae), have been widely used in both food industry and medical applications because of their excellent physical functional properties that are used as gelling, thickening and stabilizing agent. Several studies showed biological properties of carrageenans such as antiviral, anticoagulant, antitumor, antioxidant, anti-inflammatory and immune-modulatory activity. 

Aims: This study is to bring a short overview of the potential of carrageenans in foods and medical applications based on their biological activities.

Methods: This short overview used relevant works and articles examined that collected through several electronic database including PubMed, Science Direct, Springer Link and Google Scholars for the years 1991-2018 with full text in English.

Results: This study is an alternative approach that is necessary in order to present the potential of carrageenans in foods and medical applications.The advantages of carrageenans as a food additive and pharmaceutical formulation lie on their high availability, low cost, and low induction of resistance. 

Conclusion: This review suggested that carrageenans are suitable to be applied in many kinds of food products as gelling and thickening agent with their antioxidant potency as well as medical applications such as pharmaceutical formulations in drug delivery and experimental medicine. However, more comprehensive studies on toxicity and side effect of carrageenans are necessary.

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References

Rocha de Souza MC, Marques CT, Guerra Dore CM, Ferreira da Silva FR, Oliveira Rocha HA, Leite EL. Antioxidant activities of sulfated polysaccharides from brown and red seaweeds. J Appl Phycol. 2007;19(2):153-60.

van de Velde F, De Ruiter GA. Carrageenan. Biopolymers online. 2005.

Campo VL, Kawano DF, da Silva DB, Carvalho I. Carrageenans: Biological properties, chemical modifications and structural analysis–A review. Carbohydrate Polymers. 2009;77(2):167-80.

Necas J, Bartosikova L. Carrageenan: a review. Veterinarni Medicina. 2013;58(6).

Tobacman JK. Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environmental health perspectives. 2001;109(10):983.

Pangestuti R, Kim SK. Biological activities of carrageenan. Adv Food Nutr Res. 2014;72:113-24.

Li L, Ni R, Shao Y, Mao S. Carrageenan and its applications in drug delivery. Carbohydrate polymers. 2014;103:1-11.

Diogo JV, Novo SG, Gonzalez MJ, Ciancia M, Bratanich AC. Antiviral activity of lambda-carrageenan prepared from red seaweed (Gigartina skottsbergii) against BoHV-1 and SuHV-1. Res Vet Sci. 2015;98:142-4.

Kalitnik A, Barabanova AB, Nagorskaya V, Reunov A, Glazunov V, Solov'eva T, et al. Low molecular weight derivatives of different carrageenan types and their antiviral activity. Journal of applied phycology. 2013;25(1):65-72.

Buck CB, Thompson CD, Roberts JN, Müller M, Lowy DR, Schiller JT. Carrageenan is a potent inhibitor of papillomavirus infection. PLoS pathogens. 2006;2(7):e69.

Rodriguez A, Kleinbeck K, Mizenina O, Kizima L, Levendosky K, Jean-Pierre N, et al. In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition. Antiviral Res. 2014;108:88-93.

de SF-Tischer PC, Talarico LB, Noseda MD, Guimarí£es SMPB, Damonte EB, Duarte MER. Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus. Carbohydrate polymers. 2006;63(4):459-65.

Girond S, Crance J, Van Cuyck-Gandre H, Renaudet J, Deloince R. Antiviral activity of carrageenan on hepatitis A virus replication in cell culture. Research in virology. 1991;142(4):261-70.

Roberts JN, Buck CB, Thompson CD, Kines R, Bernardo M, Choyke PL, et al. Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan. Nat Med. 2007;13(7):857-61.

Wang W, Zhang P, Yu G-L, Li C-X, Hao C, Qi X, et al. Preparation and anti-influenza A virus activity of κ-carrageenan oligosaccharide and its sulphated derivatives. Food chemistry. 2012;133(3):880-8.

Gonzalez M, Alarcon B, Carrasco L. Polysaccharides as antiviral agents: antiviral activity of carrageenan. Antimicrobial agents and chemotherapy. 1987;31(9):1388-93.

Eccles R, Meier C, Jawad M, Weinmüllner R, Grassauer A, Prieschl-Grassauer E. Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Respiratory research. 2010;11(1):108.

Koenighofer M, Lion T, Bodenteich A, Prieschl-Grassauer E, Grassauer A, Unger H, et al. Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials. Multidisciplinary respiratory medicine. 2014;9(1):57.

Carlucci M, Scolaro L, Damonte E. Inhibitory action of natural carrageenans on Herpes simplex virus infection of mouse astrocytes. Chemotherapy. 1999;45(6):429-36.

Reunov A, Nagorskaya V, Lapshina L, Yermak I, Barabanova A. Effect of κ/β-Carrageenan from red alga Tichocarpus crinitus (Tichocarpaceae) on infection of detached tobacco leaves with tobacco mosaic virus/Effekt von κ/β-Karragheen aus der Rotalge Tichocarpus crinitus (Tichocarpaceae) auf die Infektion abgeschnittener Tabakblätter mit Tabakmosaikvirus. Zeitschrift für Pflanzenkrankheiten und Pflanzenschutz/Journal of Plant Diseases and Protection. 2004:165-72.

Nagorskaya V, Reunov A, Lapshina L, Yermak I, Barabanova A. Influence of κ/β-carrageenan from red alga Tichocarpus crinitus on development of local infection induced by tobacco mosaic virus in Xanthi-nc tobacco leaves. Biology Bulletin. 2008;35(3):310-4.

Nagorskaya V, Reunov A, Lapshina L, Ermak I, Barabanova A. Inhibitory effect of κ/β-carrageenan from red alga Tichocarpus crinitus on the development of a potato virus X infection in leaves of Datura stramonium L. Biology bulletin. 2010;37(6):653-8.

Carlucci MJ, Pujol CA, Ciancia M, Noseda MD, Matulewicz MC, Damonte EB, et al. Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: correlation between structure and biological activity. International Journal of Biological Macromolecules. 1997;20(2):97-105.

Silva F, Dore C, Marques C, Nascimento M, Benevides N, Rocha H, et al. Anticoagulant activity, paw edema and pleurisy induced carrageenan: Action of major types of commercial carrageenans. Carbohydrate Polymers. 2010;79(1):26-33.

Yermak IM, Barabanova AO, Aminin DL, Davydova VN, Sokolova EV, Solov'eva TF, et al. Effects of structural peculiarities of carrageenans on their immunomodulatory and anticoagulant activities. Carbohydrate polymers. 2012;87(1):713-20.

Liang W, Mao X, Peng X, Tang S. Effects of sulfate group in red seaweed polysaccharides on anticoagulant activity and cytotoxicity. Carbohydr Polym. 2014;101:776-85.

de Araujo CA, Noseda MD, Cipriani TR, Goncalves AG, Duarte ME, Ducatti DR. Selective sulfation of carrageenans and the influence of sulfate regiochemistry on anticoagulant properties. Carbohydr Polym. 2013;91(2):483-91.

Matsumoto K, Obara S, Kuroda Y, Kizu J. Anti-inflammatory effects of linezolid on carrageenan-induced paw edema in rats. J Infect Chemother. 2015;21(12):889-91.

Yao ZA, Xu L, Wu HG. Immunomodulatory function of kappa-carrageenan oligosaccharides acting on LPS-activated microglial cells. Neurochem Res. 2014;39(2):333-43.

Yuan H, Song J, Li X, Li N, Dai J. Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides. Cancer Lett. 2006;243(2):228-34.

Prasedya ES, Miyake M, Kobayashi D, Hazama A. Carrageenan delays cell cycle progression in human cancer cells in vitro demonstrated by FUCCI imaging. BMC Complement Altern Med. 2016;16:270.

Zhou G, Sheng W, Yao W, Wang C. Effect of low molecular lambda-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu. Pharmacol Res. 2006;53(2):129-34.

Yuan H, Song J, Li X, Li N, Liu S. Enhanced immunostimulatory and antitumor activity of different derivatives of κ-carrageenan oligosaccharides from Kappaphycus striatum. Journal of Applied Phycology. 2011;23(1):59-65.

Zhou G, Sun Y, Xin H, Zhang Y, Li Z, Xu Z. In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus. Pharmacol Res. 2004;50(1):47-53.

Yuan H, Song J. Preparation, structural characterization and in vitro antitumor activity of kappa-carrageenan oligosaccharide fraction from Kappaphycus striatum. Journal of Applied Phycology. 2005;17(1):7-13.

Haijin M, Xiaolu J, Huashi G. A κ-carrageenan derived oligosaccharide prepared by enzymatic degradation containing anti-tumor activity. Journal of Applied Phycology. 2003;15(4):297-303.

Usov A. Structural analysis of red seaweed galactans of agar and carrageenan groups. Food Hydrocolloids. 1998;12(3):301-8.

Zhang B, Fang CD, Hao GJ, Zhang YY. Effect of kappa-carrageenan oligosaccharides on myofibrillar protein oxidation in peeled shrimp (Litopenaeus vannamei) during long-term frozen storage. Food Chem. 2018;245:254-61.

Thevanayagam H, Mohamed SM, Chu W-L. Assessment of UVB-photoprotective and antioxidative activities of carrageenan in keratinocytes. Journal of applied phycology. 2014;26(4):1813-21.

Rafiquzzaman S, Ahmed R, Lee JM, Noh G, Jo G-a, Kong I-S. Improved methods for isolation of carrageenan from Hypnea musciformis and its antioxidant activity. Journal of applied phycology. 2016;28(2):1265-74.

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Published

2018-06-30

How to Cite

Noor, H. M. (2018). Potential of Carrageenans in Foods and Medical Applications. GHMJ (Global Health Management Journal), 2(2), 32-36. https://doi.org/10.35898/ghmj-22188

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